Examining The Relationship Between Bone Reoxygenation and Bone Mineral Density Using Near Infrared Spectroscopy and Dual X-Ray Absorptiometry
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Authors
Cusack, Mariella
Issue Date
2025-04-03
Type
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Abstract
Description
The research being presented is unique within its subject field because it is aimed
at a specific and younger demographic than previous studies. The study aims to explore the
relationship between bone reoxygenation and bone mineral density. It seeks to determine if it is
possible to make conclusions about bone mineral density based on hemodynamic responses,
measured using Near Infrared Spectroscopy (NIRS) and Dual X-Ray Absorptiometry (DXA)..
This work is novel in its approach of using one method, NIRS, a non-invasive technology, to
measure blood flow to the bone tissue. NIRS can measure the oxyhemoglobin and
deoxyhemoglobin concentrations. It is able to track various variables surrounding the
desaturation and reperfusion of oxygen (by measuring oxyhemoglobin concentrations) in the
given tissue. Subjects undergo an occlusion protocol while wearing the NIRS probe on their right
proximal tibia. The NIRS is able to record the occlusion, and analysis is conducted of the first
three seconds post occlusion, as well as the maximum hyperemic response. The DXA scanner is
used to scan the right proximal tibia of the participant and from there, a localized bone mineral
density reading is recorded. The data analysis involves using results from the participant’s intake
demographic surveys, their NIRS results, and the bone density results. They are analyzed with a
two-sample T-test. The hypotheses being explored look at the correlation of the reoxygenation
rate of bone to the bone mineral density, then additionally from a sex-based perspective, as well
as from an activity level perspective. Current results may be indicative of a positive trend for a
sex-based correlation.