Synthesis of a Sulfur-Bridged Platinum(II) Dimer
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Authors
Sircely, Samuel
Issue Date
2025-04-03
Type
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Abstract
Description
Complexes containing platinum-sulfur-copper motifs are of interest to provide insight into the interactions between cisplatin and sulfur-containing biological molecules. Cisplatin is a chemotherapy agent used since the 1970s to treat reproductive, urinary, and respiratory cancers. The reaction of a platinum(II) phosphine with ethanedithiol in the presence of the copper(I) salt, (CH3CN)4Cu(BF4), yielded a platinum dimer species with no Pt-S-Cu motif in the compound. The dimer consisting of a dithiol bridge was isolated and characterized using 13C NMR and X ray crystallography. This poster will discuss the synthesis of this compound as well as further investigation into reaction conditions