International Law and the Russio-Ukraine War
Loading...
Authors
Kucera, Helena
Issue Date
2025-04-03
Type
Language
Keywords
Alternative Title
Abstract
Description
Investigating the ability of a b-diketiminato ligand with thioether tethers (a Schiff base) to
coordinate to d8 and d9 metal center complexes whose characterization can help explain
interactions between cisplatin and sulfur-containing biological molecules. Cisplatin is a
known chemotherapy agent that has been FDA approved for use against reproductive
cancers since 1978. Potential complexes to help investigate these interactions include
compound 1, a dimetallated molecule with compound 2 as a backbone. In this work
the Schiff base, compound 2, was synthesized by reaction of acetylacetone with 2-
aminothiophenol. In addition to the desired product, compound 3 was isolated as a
byproduct using column chromatography and characterized using X-ray crystallography.
Compound 2 was characterized using 1H and 13C NMR. It was then reacted with
(PPh3)2NiCl2 in air-free processes using Schlenk techniques. This presentation will
discuss the synthesis of the ligand as well as the interaction of compound 2 with metal
complexes.